Study the role of bacterial neuraminidase against adenocarcinoma cells in vivo

Biological therapy is opening up a new age for the treatment of cancer. The bacteria -cancer interaction was firstly observed by Busch and Fehleisen (1). To reducing potential pathogenicity using active bacterial, bacterial products like proteins, enzymes, immune-toxins, that straightaway target malignancy cells regress volume tumor through expansion inhibition, induction apoptosis (2). This study aimed at testing antiangiogenic neuraminidase against mammalian adenocarcinoma AN3 transplanted into syngeneic immunocompetent mice intratumoral injection to determine antitumor activity in vivo. Histopathological sections treated mass demonstrated proliferation granulation tissue with substantial necrosis region. indicated role solid when compared an untreated group which confirmed feature makes it as anti-tumor agent.